Pothos propagation begins with the root nodes on the stem right below the leaf or branch junctures. These tiny bumps on the stems of rooting Pothos are the key to propagating Pothos. The first method of propagating Pothos is to place the cut ends of your stems in water. About a month after the roots begin to show, you can plant the cuttings in soil and treat them as you would any other houseplant. Meanwhile, the preferred method of how to propagate a Pothos begins the same as the first, and it's by taking the cuttings and remove the first leaf above the cut ends.

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Source: Gardening Know How