Pothos is considered to be one of the most favorite houseplants there is, as they aren’t fussy about light or water or fertilization. Propagating them shouldn't be a problem to you, as it begins with the root nodes on the stem right below the leaf or branch junctures. Begin by snipping off lengths of healthy stem for your Pothos cuttings, making sure each cutting has four or more leaves. Remove the leaf that’s closest to the cut end, then it's the right time to start rooting.

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Source: Gardening Know How